COMPUTER PREDICTION AND SYNTHESIS OF NEW AZOLES BASED ON N-BENZOYL-N'-(9,10-DIOXO-9,10-DIHYDROANTHRACEN-1-YL)THIOUREAS

Authors

  • V. Zvarych Lviv Polytechnic National University
  • М. Stasevych Lviv Polytechnic National University
  • О. Stanko Lviv Polytechnic National University
  • V. Novikov Lviv Polytechnic National University
  • М. Vovk Institute of Organic Chemistry of NASU
  • V. Poroikov Orekhovich Institute of Biomedical Chemistry of Russian Academy of Medical Sciences
  • O. Solovyov Shupyk National Medical Academy of Postgraduate Education

DOI:

https://doi.org/10.5755/j01.ct.64.2.6018

Keywords:

9, 10-anthraquinones, benzoylthioureas, cyclization, thiazol-2-imines, 1, 2, 4-triazoles

Abstract

New thiazole and 1,2,4-triazole derivatives of 9,10-anthraquinone were obtained by the reaction of N-benzoyl-N'-(9,10-dioxo-9,10-dihydroanthracene-1-yl)-thioureas with bromoacetone in the presence of triethylamine and hydrazine hydrate in chloroform, respectively. The PASS computer program was used to predict the biological activity spectra and to determine the most promising biological activities for experimental testing. Thus, it has been shown that the synthesized compounds are a promising class for the creation of substances with a wide range of biological activity.

DOI: http://dx.doi.org/10.5755/j01.ct.64.2.6018

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Published

2013-12-23

Issue

Section

TECHNOLOGY OF ORGANIC MATERIALS