SYNTHESIS, ANTIBACTERIAL AND ANTIOXIDANT EVALUATION OF 4-SUBSTITUTED 1-(4-METHOXYPHENYL)PYRROLIDIN-2-ONES

Authors

  • K. Anusevičius Kaunas University of Technology
  • E. Slaninaitė Kaunas University of Technology
  • I. Jonuškienė Kaunas University of Technology
  • B. Sapijanskaitė Kaunas University of Technology
  • R. Vaickelionienė Kaunas University of Technology
  • V. Mickevičius Kaunas University of Technology

DOI:

https://doi.org/10.5755/j01.ct.65.1.8881

Keywords:

1, 4-disubstituted pyrrolidin-2-ones, azoles, antibacterial, antioxidant activities

Abstract

4-Substituted 1-(4-methoxyphenyl)pyrrolidin-2-ones containing azole, diazole, oxadiazole, thiadiazole, and triazole fragments have been synthesized, and the characterization of the obtained products is presented. The study compounds have been analyzed for antioxidant and antibacterial activities. Two types of hetero systems – 5-thioxo-4,5-dihydro-1,3,4-oxadiazole and [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine – showed a moderate activity against Rhizobium radiobacter, Xanthomonas campestris, and Escherichia coli microorganisms. Some compounds were tested for their antioxidant activity.

DOI: http://dx.doi.org/10.5755/j01.ct.65.1.8881

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Published

2014-12-10

Issue

Section

TECHNOLOGY OF ORGANIC MATERIALS